Effect analysis of Lvis stent-assisted coiling embolization of intracranial wide-necked microaneurysms / 中国脑血管病杂志

; Objective To investigate the safety and efficacy of Lvis stent in the treatment of intracranial wide-necked microaneurysms. Methods From May 2016 to May 2018, 54 consecutive patients with intracranial wide-necked microaneurysms and were treated with Lvis stent-assisted coiling embolization at Department of Neurosurgery, Sichuan Provincial People's Hospital were recruited. The clinical data and treatment outcomes were retrospectively analyzed. Raymond classification was used to evaluate the results of aneurysm embolization immediately after intervention and 6 to 12 months after interventioa Regular clinical follow-up was conducted at 1, 3, 6 and 12 months after intervention, and every year thereafter. Reexamination by DSA was performed at 6 to 12 months after surgery to evaluate aneurysm embolization, stent displacement, stent stenosis, etc. The modified Rankin scale (mRS) score was used to evaluate the prognosis. Results Lvis stent-assisted coiling embolization were all successfully performed in 54 patients. Immediate postoperative embolization results of 54 aneurysms; Raymond classification I in 49 cases (90. 7%); Raymond classification II in 5 cases (9. 3%). Complete stent expansion was in 53 patients and incomplete in 1 patient. Forty-there patients received DSA follow-up at 6-12 months after interventions, with Raymond classification I in 42 cases (97. 7%) and classification II in 1 case (2. 3%). Fifty-four cases had clinical follow-ups without recurrent bleeding, death or disability. The mRS score was 0 in 52 cases and 1 in 2 cases. None of the 54 patients had any stroke during the follow-up periods. Conclusions Lvis stent-assisted coiling embolization is safe and effective in the treatment of intracranial wide-necked microaneurysm. The long-term efficacy remains to be confirmed by larger studies with longer follow-up duration.

Experimental study on animal with automatic drug injection based on predictive control for vascular interventional therapy / 生物医学工程学杂志

This paper focuses on the animal experiment of automatic drug delivery based on predictive control for vascular interventional therapy. Improvement of drug delivery system based on predictive control used in simulated experiments was put forward after the presence of time varying parameters and the characteristics of individual differences of animal had been studied. The adaptability of time varying parameters and fault tolerance of the system were also enhanced. Different injection methods were tested on animals. It is proved that higher target blood concentration can be reached while injecting during diastolic than that while injecting during systolic or injecting at a constant speed within the whole cardiac cycle. The results also showed that the improved drug injection system based on predictive control which synchronizes with the cardiac cycle could be applied to clinical trials.